44 research outputs found
Applying Rasch analysis to evaluate measurement equivalence of different administration formats of the Activity Limitation scale of the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR)
Full text linkEquivalence and noninferiority trials – are they viable alternatives for registration of new drugs? (III)
Get PDFThe scientific community's reliance on active-controlled trials is steadily increasing, as widespread agreement emerges concerning the role of these trials as viable alternatives to placebo trials. These trials present substantial challenges with regard to design and interpretation as their complexity increases, and the potential need for larger sample sizes impacts the cost and time variables of the drug development process. The potential efficacy and safety benefits derived from these trials may never be demonstrated by other methods. Active-controlled trials can develop valuable data to inform both prescribers and patients about the dose- and time-dependent actions of any new drug and can contribute to the management and communication of risks associated with the relevant therapeutic products
The role of peptides in bone healing and regeneration: A systematic review
Get PDFBackground: Bone tissue engineering and the research surrounding peptides has expanded significantly over the last few decades. Several peptides have been shown to support and stimulate the bone healing response and have been proposed as therapeutic vehicles for clinical use. The aim of this comprehensive review is to present the clinical and experimental studies analysing the potential role of peptides for bone healing and bone regeneration. Methods: A systematic review according to PRISMA guidelines was conducted. Articles presenting peptides capable of exerting an upregulatory effect on osteoprogenitor cells and bone healing were included in the study. Results: Based on the available literature, a significant amount of experimental in vitro and in vivo evidence exists. Several peptides were found to upregulate the bone healing response in experimental models and could act as potential candidates for future clinical applications. However, from the available peptides that reached the level of clinical trials, the presented results are limited. Conclusion: Further research is desirable to shed more light into the processes governing the osteoprogenitor cellular responses. With further advances in the field of biomimetic materials and scaffolds, new treatment modalities for bone repair will emerge
Atypical Femoral Fracture Post Total HIP Replacement in a Patient with HIP Osteoarthritis and an Ipsilateral Cortical Thickening
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Plateau 'pop-up' in the great 1897 Assam earthquake.
No full textThe great Assam earthquake of 12 June 1897 reduced to rubble all masonry buildings within a region of northeastern India roughly the size of England, and was felt over an area exceeding that of the great 1755 Lisbon earthquake. Hitherto it was believed that rupture occurred on a north-dipping Himalayan thrust fault propagating south of Bhutan. But here we show that the northern edge of the Shillong plateau rose violently by at least 11 m during the Assam earthquake, and that this was due to the rupture of a buried reverse fault approximately 110 km in length and dipping steeply away from the Himalaya. The stress drop implied by the rupture geometry and the prodigious fault slip of 18 +/- 7 m explains epicentral accelerations observed to exceed 1g vertically and surface velocities exceeding 3 m s-1 (ref. 1). This quantitative observation of active deformation of a 'pop-up' structure confirms that faults bounding such structures can penetrate the whole crust. Plateau uplift in the past 2-5 million years has caused the Indian plate to contract locally by 4 +/- 2 mm yr-1, reducing seismic risk in Bhutan but increasing the risk in northern Bangladesh
