45 research outputs found
Benign splenosis mimicking peritoneal seeding in a bladder cancer patient: a case report
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Functional polymorphisms in the P2X7 receptor gene are associated with stress fracture injury
Get PDFContext: Military recruits and elite athletes are susceptible to stress fracture injuries. Genetic predisposition has been postulated to have a role in their development. The P2X7 receptor (P2X7R) gene, a key regulator of bone remodelling, is a genetic candidate that may contribute to stress fracture predisposition.
Objective: To evaluate the putative contribution of P2X7R to stress fracture injury in two separate cohorts, military personnel and elite athletes.
Methods: In 210 Israeli Defence Forces (IDF) military conscripts, stress fracture injury was diagnosed (n=43) based on symptoms and a positive bone scan. In a separate cohort of 518 elite athletes, self-reported medical imaging scan-certified stress fracture injuries were recorded (n=125). Non-stress fracture controls were identified from these cohorts who had a normal bone scan or no history or symptoms of stress fracture injury. Study participants were genotyped for functional SNPs within the P2X7R gene using proprietary fluorescence-based competitive allele-specific PCR assay. Pearson Chi-square (χ2) tests, corrected for multiple comparisons, were used to assess associations in genotype frequencies.
Results: The variant allele of P2X7R SNP rs3751143 (Glu496Ala- loss of function) was associated with stress fracture injury, while the variant allele of rs1718119 (Ala348Thr- gain of function) was associated with a reduced occurrence of stress fracture injury in military conscripts (P<0.05). The association of the variant allele of rs3751143 with stress fractures was replicated in elite athletes (P<0.05), whereas the variant allele of rs1718119 was also associated with reduced multiple stress fracture cases in elite athletes (P<0.05).
Conclusions: The association between independent P2X7R polymorphisms with stress fracture prevalence supports the role of a genetic predisposition in the development of stress fracture injury
Abnormal radioiodine uptake on post-therapy whole body scan and sodium/iodine symporter expression in a dermoid cyst of the ovary: report of a case and review of the literature
Full text linkSpatiotemporal Distribution of Linear Microcracks and Diffuse Microdamage Following Daily Bouts of Fatigue Loading of Rat Ulnae
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Do capacitively coupled electric fields accelerate tibial stress fracture healing?
Get PDFBackground: Tibial stress fractures increasingly affect athletes and military recruits, with few known effective management options. Electrical stimulation enhances regular fracture healing but the effect on stress fractures has not been definitively tested. Hypothesis: Capacitively coupled electric field stimulation (CCEFS) will accelerate tibial stress fracture healing. Study design: Double blind, randomized controlled clinical trial. Methods: 20 men and 24 women with acute posteromedial tibial stress fracture were referred from local clinicians. Subjects were randomly assigned active or placebo CCEFS to be applied for 15 hours per day until healed, given supplemental calcium and instructed to rest from provocative training. Healing was confirmed when hopping to 10 cm for 30 seconds could be achieved without pain. Results: No difference in time to healing was detected between treatment and placebo groups. Females in the treatment group healed more slowly than males (p = 0.05). Superior treatment compliance was associated with reduced time to healing (p = 0.003). Rest non-compliance was associated with increased time to healing (p = 0.05). Conclusions: Whole group analysis did not detect an effect of CCEFS on tibial stress fracture healing, however, greater device use and less weight bearing loading enhanced the effectiveness of the active device. More severe stress fractures healed more quickly with CCEFS. Clinical relevance: While the use of CCEFS for tibial stress fracture healing may not be efficacious for all, it may be indicated for the more severely injured or elite athlete/recruit whose incentive to return to activity may motivate superior compliance.Full Tex
The Incidence and Risk Factors in the Development of Medial Tibial Stress Syndrome among Naval Recruits
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